EDIN
Cephradine BP

Edin (Cephradine BP) is a Cephalosporin antibiotic with broad spectrum bactericidal activity against both gram-positive and gram-negative bacteria. It is also highly active against most strains of penicillinase producing staphylococci. The organisms sensitive to Cephradine are :

Gram-positive : Staphylococci (both penicillin sensitive and resistant strains), Streptococci including both Streptococcus pyogenes (beta haemolytic) and group D streptococci (enterococci) and Streptococcus pneumoniae.

Gram-negative : E. coli, Klebsiella, P. mirabilis, Haemophilus influenza, Shigella spp. (Including Salmonella typhi) and Neisseria spp. Enterococci (s. faecallis) and many strains of E. coli and Staphylococcus aureus are also susceptible.

Edin (Cephradine) is rapidly absorbed from the gastrointestinal tract. Absorption is delayed by presence of food although the total amount absorbed is not appreciably altered.

COMPOSITION :
Edin 250 capsule : Each capsule contains Cephradine BP 250 mg.
Edin 500 capsule : Each capsule contains Cephradine BP 500 mg.
Edin Dry Syrup : When dispensed each 5 ml. Contains 125 mg. of Cephradine BP activity.
Edin Drop : When dispensed each 1.25 ml. Contains 125 mg. of Cephradine BP activity.

INDICATION :
Edin (cephradine) is used in the treatment of infections caused by sensitive organisms.

Upper respiratory tract infections : Pharyngitis, sinusitis, otitis media, tonsilitis, laryngotracheo-bronchitis.

Lower respiratory tract Infections : Acute and chronic bronchitis, lobar and bronchopneumonia.

Urinary tract infections : Cystitis, urethritis, pyelonephritis.

Gastrointestinal tract infections : Bacillary dysentery, enteritis, peritonitis.

Skin and soft tissue infections : Abscess, cellulitis, furunculosis, impetigo.

Surgical prophylaxis : It is also used in preoperative prophylactic administration (preoperatively, intra-operatively and post-operatively). In cesarean section, intra-operative (after clamping the umbilical cord) and post-operative use may reduce the incidence of certain post-operative infections.

DOSAGE AND ADMINISTRATION :
The dosage may be given without regard to meals.

Adult :
Oral : The usual dose is 1-2 gm daily in 2 to 4 divided doses. In severe and prolonged infection, the dose can be increased up to 4 gm daily which should be taken in equally divided doses.
Special dose in the following infections :
Skin and skin structures and respiratory tract infections : Usual dose is 250 mg. every 6 hours or 500 mg every 12 hours.
Lobar Pneumonia : 500 mg every 6 hours or 1 gm every 12 hours.
Urinary tract infections : Usual dose is 500 mg every 12 hours.
Gastro-intestinal tract infections : 500 mg three to four times daily.

Children :
Oral : The usual total dose is 25 to 50 mg/kg/day given in 2 to 4 equally divided doses.
Therapy should be continued for a minimum of 48-72 hrs, after the patient becomes asymptomatic or evidence of bacterial eradication has been obtained.

DOSAGE IN RENAL IMPAIRMENT :
In patients with impaired renal function, doses and frequency of administration of Cephradine must be modified according to the degree of impairment, severity of infection, susceptibillty of the causative organism and serum concentration of the drug. For adults, a loading dose of 750 mg should be given subsequently followed by 500 mg with the mentioned time interval.

For children, dosage schedule may need to be adjusted.


Reconstitution & Administration :
Oral Capsule or syrup : For the syrup, shake the bottle well before adding water. Then add 60 ml water after boiling (with the help of the provided teaspoon) to the bottle. Then continue shaking the bottle gently until the powder is dissolved properly. Shake the bottle well before each use.
For drop : Add 10 ml water after boiling (two teaspoonful) to the bottle.
Adverse Effect : Adverse effects include nausea, vomiting, diarrhoea and abdominal discomfort. Allergic reactions including skin rashes, urticaria, eosinophilia, angioedema and anaphylaxis may occur and elevation of hepatic enzyme values have been noted. Neutropenia has been reported. Super-infection with resistant microorganisms, particulary candida, may follow the treatment. There is also a possibility of development of pseudomembranous colitis.
Precaution : Cephradine should be used with caution in those patients who are known hypersensitive to penicillins.
Pregnancy and lactation : Although there have been no reports of adverse effect on the fetus, safety of use during pregnancy only when clearly indicated, Cephalosporins are distributed into breast milk and the drug should be used with caution in nursing women.
Pharmaceutical Precaution : Cephradine capsule, dry powder for syrup and dry powder for drop should be kept in a cool and dry place, protect from light.

HOW SUPPLIED :
Edin 500 capsule : Box containing 5 x 4 capsules in Alu/Alu foil pack.
Edin 250 capsule : Box containing 5 x 6 capsules in Alu/Alu foil pack.
Edin Dry Syrup : Bottle of 100 ml.
Edin Drop : Bottle of 15 ml.