Ranitidine Film Coated Tablet
Ranidil Tablet : Each film coated round tablet
contains Ranitidine 150 mg as Ranitidine hydrocloride
The active ingredient of Ranidil 150 Tablet is Ranitidine
Hydrochoride. Ranidil is a histamine H2 receptor antagonist.
It inhibits basal and stimulated secretion of gastric
acid. Ranidil is rapidly absorbed after oral administration.
Food or antacid does not interfere its absorption.
Ranidil tablet is indicated for the treatment
of duodenal ulcer, benign gastric ulcer, postoperative
ulcer, reflux esophagitis, Zollinger-Ellison syndrome
and in other conditions where reduction of gastric actidity
Ranitidine is potent histamine H2 receptor antagonist
and inhibits gastric acid secretion elicited by histamine.
Ranitidine also inhibits acid secretion elicited by
gastrin and, to a lesser extent, by muscarinic agonists.
Ranitidine inhibits basal and nocturnal acid secretion
and that stimulated by food, fundic distention, and
various drugs, It reduces both the volume and acid concentration
of gastric juice. The output of pepsin and secretion
of intrinsic factor are reduce.
Ranitidine is readily absorbed from the gastrointestinal
tract with pack concentrations in plasma occuring about
2 to 3 hours after oral administration. The bioavailability
of ranitidine is about 50% due to first-pass metabolism.
The elimination half-life from plasma is around 2 to
3 hours and ranitidine is weakly bound to plasma protein
(about 15%). A small proportion of ranitidine is metabolized
in the liver and is excreted unchanged in the urine.
Ranitidine crosses the placental barrier and is excreted
into breast milk.
DOSAGE AND ADMINISTRATION
--> Duodenal and Gastric ulcer: The usual dosage
is 150 mg twice daily taken in the morning and evening
or 300 mg as a single dose at night for 4 to 8 weeks.
--> Reflux esophagitis: 150 mg twice daily or 300
mg at bed time for up to 8 weeks.
--> Zollinger-Ellison syndrome: 150 mg 3 times daily,
if necessary increased up to 6g daily in divided doses.
Dosages should be continued as long as clinically indicated.
--> Episodic Dyspepsia: 150 mg twice daily for 6
--> Maintenance theraphy: 150 mg at night for preventing
Ranitidine is well tolerated and side effects
are usually uncommon. Altered bowel habit, dizziness,
rash, tiredness, reversible confusional states, headache,
decreased blood counts, muscle or join pain have rarely
Ranitidine should be given in reduced dosage
to patients with impaired renal and hepatic function.
Ranitidine crosses the placenta. But there is
no evidence of impaired fertility or harm to the fetus
due to Ranitidine. Like other drugs, Ranitidine should
only be used during pregnancy if considered essential.
Ranitidine is excreted in human breast milk.
Caution should be exercised when the drug is administered
to a nursing mother.
Store in a Cool and dry place. Protect from light.
Ranidil Tablet : Box contains 100 Tablets in
10 x 10's Alu Alu foil pack.