Lactulose USP 3.35 gm / 5 ml
Concentrated oral solution
Each 5 ml Mebolos concentrated oral solution contains
Lactulose USP 3.35 gm.
Lactulose is a disaccharide, which is not hydrolyzed in the small intestine. Therefore it can not be absorbed and is transported to the colon with water to retain the osmotic balance. It provides a natural substrate for the saccharolytic bacterial flora in the colon. In the colon, several species of bacteria can hydrolyze Lactulose to the monosaccharides galactose and fructose. By encouraging this normal metabolic activity of the bacteria, the osmotic pressure of the colonic contents is doubled and more water is drawn into the bowel. Further metabolism of the monosaccharides leads to the production of acetic acids and the subsequent lowering of colonic pH. This acidification of the colonic contents is considered to be the main reason for the effectiveness of Lactulose solution. In chronic portal systemic encephalopathy if may be associated with the decrease in the relative concentration of free ammonia, the major agent involved in the cerebral disturbance.
Indications and Usage:
2. Hepatic encephlopathy (Portal systemic encephalopathy) : hepatic coma.
Dosage and Administration:
Constipation: Initially Mebolos solution may be given twice daily. In due course the dose should be adjusted according to the needs of the individual, both the following serves as a guide-
Adult : (including the elderly)-15 ml twice daily.
Children : 5 to 10 years-10 ml twice daily. Children under 5 years 5 ml twice daily. Babies under 1 year 2.5 ml twice daily. Mebolos solution may, if necessary, be taken with water or fruit juice, etc.
Adults (including the elderly) Initially 30-50 ml three times a day. Subsequently adjust the dose to produce two or three soft stools each day.
Subsequently adjust the dose to produce two or three soft stools each day.
Children: No dosage recommended for this indication.
Because of Lactulose's physiological mode of action it may take up to 48 hours before effects are obtained. However, clinical experience has shown that this medicament does exhibit a 'carry-over' effect, which may enable the patient to reduce the dose gradually over a period of time. A maintenance dose of 15 ml per day provides only 14 kilocalories and is therefore, unlikely to adversely effect diabetic patients.
Galactosaemia: In common with other preparations used for the treatment of constipation, Lactulose should not be used when there is evidence of gastro-intestinal obstruction.
During the first few days of treatment, meteorism and increased flatulence may occur. These symptoms usually disappear under continued therapy. Diarrhoea may occur especially when used higher dosages, e.g. during treatment of portal systemic encephalopathy. Dosage should then be adjusted to obtain two or three formed stools per day.
Use in pregnancy :
Wide clinical experience, together with data from animal reproduction studies has not revealed any increase in embryotoxic hazard to the foetus if used in the recommended dosage during pregnancy. If laxative therapy is needed in pregnancy, use of this drug is acceptable.
Use in pregnancy & Lactation:
There is no information on the use of Aceclofenac during pregnancy. The regular use of NSAIDs during the last trimester of pregnancy may increase uterine tone and contraction. There is no information on the secretion of Aceclofenac to breast milk. The use of Aceclofenac should therefore be avoided in pregnancy and lactation unless the potential benefits to the mother outweigh the possible risks to the fetus.
Store below 250C. Do not freeze. Dilution and subsequent storage is not recommended.
Each glass bottle contains 100 ml & 200 ml Mebolos concentrated oral solution.