Use in children:
Laxod-500: Each film coated tablet contains Levofloxacin Hemihydrate INN equivalent to Levofloxacin 500 mg.
Levofloxacin is a synthetic, broad-spectrum, third generation fluoroquinolone derivative antibacterial agent for oral administration. Chemically levofloxacin is a chiral fluorinated carboxyquinolone.
Indications and Usage:
Levofloxacin is indicated for the treatment of adults (18 years of age) with mild, moderate and severe infections caused by susceptible strains of the designated micro-organisms in the condition listed below:
Acute maxillary sinusitis due to Streptococcus pneumoniae, Haemophilus influenzae or Moraxella catarrhalis.
Acute bacterial exacerbation of chronic bronchitis due to Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae or Moraxella catarrhalis.
Community-acquired pneumonia due to Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, klebsiella pneumoniae, Moraxella catarrhalis, Chlamydia pneumoniae, Legionella pneumophila or Mycoplasma pneumoniae.
Complicated urinary tract infections due to Excherichia coli, klebsiella pneumoniae or Staphylococcus saprophyticus.
Acute pyelonephritis caused by Excherichia coli.
Uncomplicated & complicated skin and soft tissue infections Including Abscesses, Cellulitis, Furuncles, Impetigo, Pyoderma, Wound infections due to staphylococcus aureus, streptococcus pyogenes, proteus mirabilis or enterococcus faecalis.
Dosage and Administration:
Acute sinusitis 500 mg once daliy for 10-14 days.
Exacedrbation of chronic bronchitis, 250-500 mg daily for 7 days.
Community acquired pneumonia 500 mg once or twice daily for 7-14 days.
Complicated urinary tract infections and acute pyelonephritis 250 mg daily for 7-14 days.
Uncomplicated skin and soft-tissue infections 500 mg once daily for 7-10 days.
Complicated skin and soft-tissue infections 750 mg once daily for 7-14 days
Levofloxacin is contraindicated in patients with a history of hypersensitivity to levofloxacin, quinolone antimicrobial agents or any other components of this product.
The following measures should be taken during administration of Levofloxacin:
White taking levofloxacin, adequate amount of water should be taken to avoid concentrated form of urine.
Dose adjustment should be exercised during levofloxacin ingestion in presence of renal insufficiency.
Levofloxacin is generally well tolerated. However, a few side-effects can usually be seen. Side-effects include nausea, vomiting, diarrhea, abdominal pain, flatulence and rare occurrence of phototoxicity (0.1%). Side-effects that may be seen very rarely include tremors, depression, anxiety, confusion etc.
Use in pregnancy & Lactation:
Levofloxacin is not recommended for use during pregnancy or nursing, as the effects on the unborn child or nursing infant are unknown.
Not recommended for children.
Antacids, Iron and Adsorbents-reduce absorption of Levofloxacin.
NSAID' may increase the risk of CNS stimulation.
Warfarin may increase the risk of bleeding
Levofloxacin exhibits a low potential for acute toxicity. However, in the events of an acute overdosage the stomach should be emptied. The patients should be kept under observation and appropriate hydration should be maintained.
Laxod-500: Box contains 5 x 6's tablets in Alu/Alu blister strip.