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HYXIM
 Key Product >>HYXIM

HYXIM
Cefixime BP

Description:
HYXIM (Cefixime) is a broad spectrum cephalosporin antibiotic of third generation for oral administration. It is a bactericidal antibiotic and is stable to hydrolysis by many beta-lactamases. HYXIM kills bacteria by interfering the synthesis of the bacterial cell wall. HYXIM is highly active against Neisseria Gonorrhoeae, Haemophilus Influenzae, Moraxella catarrhalis including beta-lactamase producers, most of the Enterobacteriaceae, Beta-Haemolytic Streptococci (Group A & B) and Streptococcus Pneumoniae, HYXIM is more active than other oral cephalosporins against Escherichia coli, Klebsiella spp, Proteus mirabilis and Serratia marcescens. HYXIM is also active against Streptococcus pyogenes. 40-50% of an oral dose is absorbed from gastro-intestinal tract, whether taken with meals or not. The plasma half-life is usually about 3 to 4 hours and may be prolonged when there is renal impairment. About 65% is bound to plasma protein. HYXIM is mainly excreted unchanged in bile and urine.

Composition:
HYXIM-200 Capsule: Each capsule contains Cefixime Trihydrate BP equivalent to anhydrous Cefixime 200 mg.

HYXIM Powder for Suspension:
After preparation each 5 ml contains Cefixime Trihydrate BP equivalent to anhydrous Cefixime 100 mg.

Indication:
It is indicated for the treatment of the following acute infection, when caused by susceptible


Microorganisms:
- Urinary tract infections : Cystitis, Cystourethritis, Pyelonephritis, Gonococcal Urethritis.
- Upper respiratory tract infections : Otitis media, and other URTI where the causative organism is known or suspected to be resistant to other commonly used antibiotics.
- Lower respiratory tract infections : Bronchitis, etc.
- Typhoid fever

Dosage and administration:
HYXIM Capsule :
Adult : 1 or 2 capsules (200-400 mg) as a single dose or in two divided doses daily for 7-14 days, according to the severity of the infection.
Children above 6 months: 8 mg per kg body weight as a single dose or in two divided doses for 7-14 days according to the severity of the infection or as following: 6 months-1 year : 3.75 ml or 75 mg
1-4 years : 5 ml or 100 mg
5-10 years : 10 ml or 200 mg
11-12 years : 15 ml or 300 mg
Above 12 years : Adult dose may be administered
Children under 6 months: Not recommended.

Side Effects:
HYXIM is generally well tolerated. The majority of adverse reactions observed in clinical trials was mild and self-limiting in nature. Gastro-intestinal disturbances : Diarrhoea (if severe diarrhoea occurs, HYXIM should be discontinued), changes in the color of stool, Nausea, Abdominal pain, Dyspepsia, Vomiting, Flatulence have been reported. Central nervous system disturbances : Headache, Dizziness, etc. Others : Hypersensitivity reactions which usually subsided upon discontinuation of therapy; infrequent and reversible haematological changes; elevation of serum amylase, etc.

Contraindications:
Patients with known Hypersensitivity to Cephalosporin Antibiotics, children under 6 months.

Cautions:
HYXIM should be prescribed with caution in individuals with a history of Gastro-Intestinal Disease, Particularly Colitis. Dosage adjustment is only necessary in severe renal failure (creatinine clearance <20 ml/ min).

Use in pregnancy and lactation:
No data are available, so it is probably best to avoid using the drug during pregnancy and by the nursing mothers.

Drug Interaction:
No data are available

Storage:
Store at normal temperature and away from sun light.

Packing:
HYXIM-200 Capsule: Box containing 1x6's capsules in alu-alu blister pack.
HYXIM Powder for Suspension: Bottle containing dry powder for Preparation of 50 ml suspension.