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GEM-20 Capsule
 Key Product >>GEM-20 Capsule

GEM-20 Capsule
Omeprazole BP 20 mg

Gem-20 (Omeprazole) is a Benzimidazole substitute which is called proton pump inhibitor. Omiprazole inhibits secretion of gastric acid by blocking hydrogen potassium adenosine triphosphatase H+/K+-ATP-ase enzyme system at the secretory surface of the gastric parietal cells gradually. After oral administration the onset of antisecretory effect occurs within an hour or two (patient to patient varies) and blocking of acid secretion lasts up to 72 hours. When Gem-20 is discontinued secretory function again starts over 3-5 days. It is safer and completely metabolized in the liver. it's half-life in general is 0.5 to 1.5 hours. After Gem-20 intake fecal excretion is 20-25% and the remainder passes through urine. Gem-20 acts faster than Ranitidine and its healing percentage higher & safer. Bioavailability varies from 50% - 65% depending on formulation.

Gem-20 capsule contains Omeprazole BP 20 mg as enteric coated gastro resistant granules.

Gem-20 is indicated in the treatment of duodenal ulcer, resistant Gastric Ulcer including NSAID's induced peptic ulcer associated with H.Pylori (Helicobacter Pylori eradication) & GERD (Gastro-esophageal reflux diseases). It is also indicated in the therapy of Zollinger-Ellison Syndrome. It is very effective in regular heart-burn, epigastric-pain symptoms and in gastro intestinal bleeding. It may also be indicated as prophylaxis in pre or post operative cases.

Dosages & Administration:
Gem-20 should be taken in empty stomach (before meal) always. General normal dose 1 Cap of 20 mg once daily. In case (adult) of duodenal ulcers or in severe recurrent cases daily once dose may be increased from 20 mg to 40 mg for 4 weeks to 8 weeks. Specially in Zollinger-Ellison cases dose may be raised & recommended from 80 mg to 180 mg daily in divided doses-if essential, keeping the patient under proper supervision in a Clinic/Hospital. In different cases and on the severity of the diseases doctors may suggest the therapeutic or prophylactic doses accordingly.

Over 2 years old in case of ulcerative reflux esophagitis, in general maintenance dose is 07-1.4mg / kg body weight for 4 to 8 weeks.

Only found in case of hypersensitivity to any such preparation or component.

Gem-20 (Omeprazole) Should not be prescribed for pregnant lady or lactating mother unless it's use is Considered as Beneficial. Be careful before treating a patient suffering from gastric malignancy.

Side Effects:
Gem-20 is almost well-tolerated but nausea, dizziness, headache, abdominal pain, skin rash or constipation / diarrhoea may occur (varies from patient to patient) but symptoms goes away when the therapy is stopped.

Drug Interaction:
While treating Patients with diazepam, Phenytoin or warfarin Omeprazole ie. Gem-20 can delay the elimination-so to get better result of Gem-20 (if added) reduction of warfarin or Phenytoin doses is necessary.

Gem-20 Capsule : Box contains 60 capsules ( 6 x 10) in Alu-Alu Blister forms.