Ciprom
Ciprofloxacin Hydrochloride USP

Description: Ciprom containing Ciprofloxacin is a synthetic quinolone anti-infective agent. Ciprofloxacin has broad spectrum of activity. It is active against most gram-negative aerobic bacteria including Enterobacteriacae and Pseudomonas aeruginosa. Ciprofloxacin is also active against gram-positive aerobic bacteria including penicillinase producing, non-penicillinase producing, and methicillin resistant staphylococci, although many strains of streptococci are relatively resistant to the drug. The bactericidal action of Ciprofloxacin results from interference with the enzyme DNA gyrase needed for the synthesis of bacterial DNA.
Following oral administration it is rapidly and well absorbed from the G.l. tract, It is widely distributed into body tissues and fluids. The half-life is about 3.5 to 4.5 hours. About 30 to 50 % of an oral dose of Ciprofloxacin is excreted in the urine within 24 hours as unchanged drug and biologically active metabolites.

Ciprom-DS Dry Powder: Each 5 ml. Suspension contains Ciprofloxacin Hydrochloride USP equivalent to 250 mg Ciprofloxacin.

Composition: Ciprom 250: Each film coated tablet contains Ciprofloxacin USP 250 mg as Ciprofloxacin Hydrochloride. Ciprom 500:Each film coated tablet contains Ciprofloxacin USP 500 mg as Ciprofloxacin Hydrochloride. Ciprom-DS dry Syrup : After reconstitution each 5 ml contains Ciprofloxacin Hcl USP equivalent to 250 mg ciprofloxacin.

Indications: Cipromis used in adults for the treatment of urinary tract infections, lower respiratory tract infections, skin and soft tissue-infections bone and joint Infections and GI infections caused by susceptible gram-negative and gram-positive aerobic bacteria. It is also used for the treatment of uncomplicated gonorrhoea caused by penicillinase producing and non-penicillinase producing Neisseria gonorrhoea.


DOSAGE AND ADMINISTRATION :
Ciprommay be given orally without regard to meals. Patients receiving Ciprofloxacin should be well hydrated and should be instructed to drink fluids liberally. Because of the risk of crystaluria, it is recommended that the usual dosage of the drug should not be exceeded.
For the treatment of urinary tract infections, the usual adult oral dosage of Ciprom for mild to moderate infections is 250 mg every 12 hours and the usual adult dosage for complicated infections, caused by organisms not highly susceptible to drug is 500 mg every 12 hours. A dosage of 750 mg every 12 hours may be needed, especially in bone and joint infections or when infections are severe or complicated. The usual adult oral dosage of Ciprom for infectious diarrhoea is 500 mg every 12 hours. For the treatment of uncomplicated urethral, endocervical or rectal gonorrhoea, caused by penicillinase producing strains of Neisseria gonorrhoeae (PPNG) or non-penicillinase producing strains of the organisms, adults should receive a single 500 mg oral dose of Ciprom followed by oral doxycycline therapy for possible co-existing Chlamydial infection. In the treatment of chancroid, 500 mg orally twice daily for 3 days is required. The duration of Ciprom therapy depends on the type and severity of infection and should be determined by the clinical and bacteriological response of the patients. For most infections one may require more prolonged therapy. Ciprofloxacin therapy may need to be continued for 4-6 weeks or longer for the treatment of bone and joint infections. Infectious diarrhoea generally is treated for 3-7 days, although less prolonged therapy. may be adequate. Modification of the usual dosages of Ciprofloxacin generally is unnecessary in patients with creatinine clearances greater than 30-50ml/minute or less, doses and/or frequency of administration of ciprofloxacin should be modified in response to the degree of renal impairment and the site and severity of infection.
Adults with creatinine clearances of 30-50 ml/minute can receive 250-500 mg of Ciprofloxacin every 12 or 18 hours. However these patients should be monitored carefully and serum ciprofloxacin concentrations determined periodically.

Precaution & Warning:
It should be used with caution in patients with suspected or known CNS disorders such as arteriosclerosis or epilepsy or other factors which predispose to seizures and convulsion.

Pregnancy, Lactation & Children: :
Not to be used in pregnancy and nursing stage. Though not recommended for the children where benefit out -weighs risk a dosage of 7.5-15 mg/kg/day in two divided dose can be given.

Contraindication:
Patients with a history to hypersensitivity to ciprofloxacin and to other quinolones and in children and in pregnant women.

Adverse Reaction:
Adverse effects include nausea and other gastrointestinal disturbances, drowsiness, headache, dizziness and skin rashes. Crystalluria has occurred with high doses.

How Supplied:
Ciprom 250 : Box containing 3 x 10 tablets in blister pack.
Ciprom 500 : Box containing 2 x 10 tablets in blister pack.

How Supplied:
Ciprom-DS dry Syrup:In 60 ml. amber glass bottle.