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Diacon-80
 Key Product >>Diacon-80

Diacon-80
Gliclazide BP 80 mg

Composition:
Each Diacon-80 tablet contains Gliclazide BP 80 mg.

Indications: Diacon-80 (Gliclazide) is indicated for control of blood glucose in patients with non-insulin dependent diabetes mellitus (Type-II, maturity onset diabetes mellitus) whose hyperglycemia cannot be controlled by diet alone.
Diacon-80 (Gliclazide) is a second-generation oral hypoglycemic sulfonylurea, which stimulates the release of insulin from pancreatic beta cells by facilitating Ca++ transport across the beta-cell membranes and decreases hepatic glucose output.

Dosage and administration: Initially, 40-80 mg daily adjusted according to response, up to 160 mg as a single dose. If necessary, up to 320 mg daily can be taken. Doses more than 160 mg daily should be given in 2 divided doses.

Contraindications: * Hypersensitivity to sulfonylurea.
* Diabetes complicated by ketoacidosis.
* Diabetic precoma and coma.
* Sole therapy of insulin-dependent (Type-I) diabetes mellitus.
* Diabetes when complicated by pregnancy.
* Breast-feeding.
* Porphyria.

Side Effects:
Hypoglycemiamay occur in concurrent conditions such as hepatic & renal diseased, alcohol intoxication and adrenal & pituitary insufficiency. Gastro-intestinal disturbances including nausea, epigastric fullness, heartburn are most common, but dose related and may disappear when dose is reduced.
Allergic skin reactions including rash, pruritus, and erythema urticarias have been reported. These may be transient and may disappear despite continued use of the drug. If skin reactions persist, discontinue the drug.
Several hematological adverse reactions such as leukopenia, thrombocytopenia, agranulocytosis, aplastic anemia, hemolytic anemia, pancytopenia, hepatic porphyria have been reported with other sulfonylureas, but have not been reported with Diacon-80.

Drug Interactions:
Androgensanticoagulants, chloramphenicol, fluconazole, miconazole, histamine H2 antagonists, MAO inhibitors, phenylbutazone, probenecid, salicylates, sulfonamides, and tricyclic antidepressants may enhance the hypoglycemic effect of Diacon-80. Beta-blockers rifampicin and thiazide diuretics, thyroid hormones, laxatives and oral contraceptives may decrease the hypoglycemic effect of Diacon-80.

Precautions: :
Care should be practised in patients with hepatic and/or renal impairment and a small starting dose should be used with careful patient monitoring. In long term clinical trials patients with renal insufficiency have been treated satisfactorily using Diacon-80 (Gliclazide) at reduced dosage.

Overdosage and treatment:
Overdosage can produce hypoglycemia.Treat mild hypoglycemia without loss of consciousness or neurologic findings aggressively with oral glucose and adjustments in drug dosage or meal patterns. Severe hypoglycemic reaction occur infrequently, but require immediate hospitalization. If hypoglycemic coma is suspected, rapidly inject concentrated (50%) dextrose IV. Followed by a continuous infusion of more dilute (10%) dextrose at a rate that will maintain the blood glucose at a level of about 100 mg/dI Storage:
Store at room temperature.

Packing:
Box containing 5x10's tablets in blister pack.